Clinical news 07/05/2025
While osteoporosis is commonly associated with post-menopausal women, it is important to recognize that the condition also significantly affects men and individuals with long-term endocrine disorders. These populations are often underdiagnosed, yet they face a heightened risk of osteoporotic fractures due to changes in bone quality that may not always be captured by standard bone mineral density (BMD) measurements.
Trabecular Bone Score (TBS) is emerging as a valuable tool in assessing bone microarchitecture and fracture risk, particularly in patients with endocrine-related conditions. Here are three key studies that highlight TBS’s potential in clinical practice:
Cushing’s Disease and Bone Recovery
Tan, Elina et al. (2024) explored how patients with Cushing’s disease experience improved TBS following the normalization of hypercortisolism, suggesting that TBS is sensitive to changes in bone quality during disease management.
Read more on PubMed
Insulin Resistance and Bone Quality
de Araújo et al. (2020) demonstrated that insulin resistance impairs bone quality—not quantity—highlighting the importance of evaluating bone microarchitecture in metabolic conditions.
Read the full article on Springer
Primary Hyperparathyroidism and Fracture Risk
Oprea et al. (2023) found that women with primary hyperparathyroidism (PHPT) exhibit significantly degraded bone microarchitecture, making TBS a powerful predictor of fracture probability in this group.
Access the article on PMC
These studies underscore the importance of incorporating TBS into the fracture risk assessment toolkit, especially for patients with endocrine disorders where bone health may be compromised in less obvious ways.
